When his family is murdered, a deaf-mute named Boy escapes to the jungle and is trained by a mysterious shaman to repress his childish imagination and become an instrument of death.
Hobbs has Dominic and Brian reassemble their crew to take down a team of mercenaries; Dominic unexpectedly gets sidetracked with facing his presumed deceased girlfriend, Letty.
Unlucky assassin Ladybug is determined to do his job peacefully after one too many gigs gone off the rails. Fate, however, may have other plans, as Ladybug's latest mission puts him on a collision course with lethal adversaries from around the globe—all with connected, yet conflicting, objectives—on the world's fastest train.