Hoping to bring his family closer together and to recreate his childhood vacation for his own kids, a grown up Rusty Griswold takes his wife and their two sons on a cross-country road trip to the coolest theme park in America, Walley World. Needless to say, things don't go quite as planned.
Eddie Garrick is a good-hearted man who has lost his belief in the wonder of Christmas. While spending time with his nine-year-old daughter Charlotte on Christmas Eve, he befriends a mysterious man in a red suit named Nick.
Dr. Lily Houghton enlists the aid of wisecracking skipper Frank Wolff to take her down the Amazon in his dilapidated boat. Together, they search for an ancient tree that holds the power to heal – a discovery that will change the future of medicine.